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Related Experiment Videos

[Sentinel node radiolocalisation and predictive value in lip squamous cell carcinoma].

Girolamo Tartaglione1, Clemente Potenza, Alessio Caggiati

  • 1SSD Medicina Nucleare, Ospedale Cristo Re, Roma. nmcrh@hotmail.com

La Radiologia Medica
|November 13, 2003
PubMed
Summary

Sentinel node (SN) radiolocalization is a valuable prognostic tool for lip squamous cell carcinomas (SCC). This method accurately maps lymphatic pathways, potentially avoiding unnecessary lymphadenectomies in early-stage T2N0M0 SCC patients.

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Surgical Oncology

Background:

  • Lip squamous cell carcinoma (SCC) staging is crucial for treatment planning.
  • Accurate assessment of lymphatic drainage is essential for T2N0M0 SCC patients.
  • Sentinel node biopsy (SNB) is a minimally invasive technique for staging nodal metastasis.

Purpose of the Study:

  • To evaluate the role and prognostic value of sentinel node (SN) radiolocalization in T2N0M0 lip SCC.
  • To determine the feasibility and accuracy of SN identification in lip SCC.
  • To assess the impact of SN biopsy on treatment decisions and patient outcomes.

Main Methods:

  • Prospective study of 11 patients with T2N0M0 lip SCC.
  • Intradermal injection of Technetium-99m Nanocoll around the tumor.

Related Experiment Videos

  • Lymphoscintigraphy performed 3 hours pre-operatively to identify SNs.
  • Selective lymphadenectomy of identified SNs.

    • Main Results:

    • SNs were successfully identified in all patients within 5 minutes of tracer injection.
    • SNs were primarily located in the submandibular (level I) and occasionally cervical (level II) areas.
    • All identified SNs were negative for metastasis, and patients remained disease-free with a median follow-up of 20 months.

    Conclusions:

    • Immediate scintigraphy is vital for precise SN localization and lymphatic mapping in lip SCC.
    • SN radiolocalization is beneficial for T2N0 stage lip SCC, potentially obviating the need for immediate comprehensive lymphadenectomy.
    • This technique offers cost and time savings in healthcare management, though larger multi-center trials are needed for validation.