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[Fever caused by neuroleptics].

J P Ottervanger1, A Gerbrandy-Colijn, B H Stricker

  • 1Bureau Bijwerkingen Geneesmiddelen, Rijswijk.

Nederlands Tijdschrift Voor Geneeskunde
|November 14, 1992
PubMed
Summary

Fever in patients taking neuroleptic drugs may signal an adverse reaction. This study reports two cases, one likely due to a drug solvent and another to neuroleptic malignant syndrome.

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Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Neuroscience

Background:

  • Neuroleptic medications are widely used for psychiatric conditions.
  • Fever can be a rare but serious adverse effect of neuroleptic drug use.
  • Identifying the cause of fever in these patients is crucial for appropriate management.

Observation:

  • Two distinct cases of patients experiencing fever while on neuroleptic therapy were documented.
  • Case 1: Fever was suspected to be a reaction to the solvent in a sustained-action neuroleptic preparation.
  • Case 2: Fever was likely associated with the neuroleptic malignant syndrome, a severe drug-induced condition.

Findings:

  • The presented cases highlight the diverse causes of fever in neuroleptic drug recipients.
  • Drug-induced fever can manifest as a direct reaction to the active pharmaceutical ingredient or excipients.
  • Neuroleptic malignant syndrome represents a critical differential diagnosis for fever in this patient population.

Implications:

  • Clinicians should consider drug-related fever when patients on neuroleptics present with elevated temperatures.
  • Differentiating between solvent reactions and neuroleptic malignant syndrome is essential for timely and effective treatment.
  • This underscores the importance of thorough patient history and medication review in diagnosing adverse drug reactions.

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