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Updated: Aug 8, 2026

A Method for Mouse Pancreatic Islet Isolation and Intracellular cAMP Determination
Published on: June 25, 2014
Metabolism of D-glucose anomers in pancreatic islets (review)
1Laboratory of Experimental Hormonology, Brussels Free University, Route de Lennik 808, B-1070 Brussels, Belgium. malaisse@ulb.ac.be
Abstract:
D-glucose metabolism displays anomeric specificity in pancreatic islets and other cell types. Recent studies have extended this knowledge to the effect of D-glucose to augment D-fructose phosphorylation by glucokinase in both pancreatic islet B-cells and hepatocytes, and have documented that the anomeric specificity of D-glucose metabolism in pancreatic islets implies enzyme-to-enzyme tunnelling of metabolites in the early steps of glycolysis. It is proposed that the anomeric specificity of D-glucose metabolism is essential to a sound understanding of carbohydrate homeostasis in health and disease.
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