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Ruta graveolens aqueous extract retards mouse preimplantation embryo development
Jorge L Gutiérrez-Pajares1, Lidia Zúñiga, José Pino
1Laboratorio de Reproducción y Biología del Desarrollo, Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos, Lima, Peru. jgutierr@genes.bio.puc.cl
Reproductive Toxicology (Elmsford, N.Y.)
|November 14, 2003
Summary
Ruta graveolens (rue) extract can harm early embryo development and transport in mice. Higher doses significantly increased abnormal embryos and reduced cell count, indicating potential reproductive risks.
Area of Science:
- Reproductive Toxicology
- Ethnobotany
- Developmental Biology
Background:
- Ruta graveolens (rue) is traditionally used for fertility regulation.
- Scientific investigation into rue's reproductive effects is limited.
Purpose of the Study:
- To evaluate the embryotoxic potential of Ruta graveolens extract.
- To assess the impact of rue on preimplantation embryo development and transport.
Main Methods:
- Aqueous extract of Ruta graveolens was administered orally to superovulated mice.
- Embryos were collected 98 hours post-hCG to assess development and transport.
- Different concentrations (5%, 10%, 20%) of rue extract were tested against a control group.
Main Results:
- Rue extract at 10% and 20% significantly increased the proportion of abnormal embryos.
- The highest dose (20%) led to a diminished embryo cell number.
- Embryo transport was slightly delayed in the 20% rue extract group.
Conclusions:
- Oral administration of Ruta graveolens extract exhibits embryotoxic effects in mice.
- Rue extract interferes with critical stages of preimplantation development.
- Findings suggest potential risks associated with traditional use of rue for fertility regulation.