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Related Experiment Videos

Hyperammonemia with complex urinary tract anomaly: a case report.

H O S Gabra1, P A Fenton, J R Bonham

  • 1Paediatric Surgical Unit, Sheffield Children's Hospital NHS Trust, Western Bank, Sheffield, UK.

Journal of Pediatric Surgery
|November 14, 2003
PubMed
Summary
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Hyperammonemia is rare in children but can occur with severe illness. This case highlights a urinary tract infection with specific bacteria causing hyperammonemic encephalopathy in a pediatric patient.

Area of Science:

  • Pediatric Nephrology
  • Infectious Diseases
  • Neurology

Background:

  • Hyperammonemia is infrequently observed in pediatric patients, typically associated with systemic illness.
  • Previous reports link hyperammonemia to urea-splitting organism infections, often post-urinary tract surgical procedures.

Observation:

  • A pediatric patient presented with severe hyperammonemic encephalopathy.
  • The patient had a concurrent urinary tract infection (UTI).

Findings:

  • This is the first reported pediatric case of hyperammonemic encephalopathy secondary to UTI caused by Staphylococcus epidermidis and Corynebacterium sp.
  • The identified bacterial species are known urea-splitters.

Implications:

Related Experiment Videos

  • Highlights a rare but serious complication of UTIs in children.
  • Suggests considering UTI as a potential cause of hyperammonemia in pediatric patients, even without prior urinary tract surgery.
  • Emphasizes the importance of prompt diagnosis and management of UTIs to prevent neurological sequelae.