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Insulin-like growth factor-II gene polymorphism is associated with primary open angle glaucoma
Fuu-Jen Tsai1, Hui-Ju Lin, Wen-Chi Chen
1Department of Medical Genetics and Pediatrics, China Medical University Hospital, Taichung, Taiwan.
Journal of Clinical Laboratory Analysis
|November 14, 2003
Summary
Insulin-like growth factor II (IGF-II) gene polymorphism is linked to primary open angle glaucoma (POAG) in Chinese individuals. The C/C homozygote of the IGF-II exon 9 Apa I C/T gene polymorphism may serve as a POAG risk marker.
Area of Science:
- Ophthalmology
- Genetics
- Neuroscience
Background:
- Hypoxia and ischemia are critical factors in glaucoma development and progression.
- Insulin-like growth factors (IGFs) are neurotrophic agents that respond to hypoxic-ischemic conditions.
Purpose of the Study:
- To investigate the association between Insulin-like Growth Factor II (IGF-II) exon 9 Apa I C/T gene polymorphism and primary open angle glaucoma (POAG).
- To identify potential genetic markers for POAG in the Chinese population.
Main Methods:
- Genotyping of 60 POAG patients and 104 healthy controls using polymerase chain reaction-based restriction analysis.
- Analysis of the IGF-II exon 9 Apa I C/T gene polymorphism distribution and genotype frequencies.
Main Results:
- Significant statistical differences in genotype frequencies of the IGF-II exon 9 gene polymorphism were observed between POAG patients and controls (P=0.010).
- The C/C homozygote demonstrated an odds ratio of 0.266 (95% CI: 0.636–0.111), suggesting a protective association.
Conclusions:
- IGF-II plays a role as a neurotrophic agent in POAG.
- The C/C homozygote of the IGF-II exon 9 Apa I C/T gene polymorphism is a potential genetic marker for POAG in the Chinese population.
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