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Treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell death via suppression on caspase-3
Hee-Hyuk Lee1, Hong Kim, Myoung-Hwa Lee
1Department of Physiology, College of Medicine, Kyung Hee University, # 1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea.
Abstract:
Intracerebral hemorrhage is one of the most devastating types of stroke. This disease is known to cause severe neurological damage and also has a very high mortality rate. In this study, the effect of treadmill exercise on intrastriatal hemorrhage-induced neuronal cell death was investigated. Intrastriatal hemorrhage was caused by injection of collagenase into the striatum using a stereotaxic instrument. Animals of the exercise group were made to run on a treadmill for 30 min once a day during 10 consecutive days. In the present results, treadmill exercise was shown to suppress the increase in the size of hemorrhage-induced lesions and the increase in caspase-3 expression in the striatum. Based on these results, it is possible that treadmill exercise aids in the recovery from central nervous system sequelae following intracerebral hemorrhage.
