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Updated: Aug 4, 2026
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A Model of Free Tissue Transfer: The Rat Epigastric Free Flap
Published on: January 15, 2017
Prefabricated skin flaps in a rat model based on a dermal replacement matrix Permacol
T M MacLeod1, G Williams, R Sanders
1Restoration of Appearance and Function Trust, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, UK. tmhighlander@yahoo.co.uk
British Journal of Plastic Surgery
|November 15, 2003
Summary
This study demonstrates that a collagen tissue matrix (Permacol) can be successfully vascularized to support skin grafts, offering a promising solution for tissue-engineered flaps in plastic surgery.
Area of Science:
- Biomaterials Science
- Plastic Surgery
- Tissue Engineering
Background:
- Reconstructing 3D structures in plastic surgery is challenging, with scaffolds often losing detail.
- Integrating blood supply into biomaterial scaffolds can improve outcomes for skin grafts.
Purpose of the Study:
- To evaluate if a porcine-derived collagen matrix (Permacol) can be vascularized via a pedicle.
- To determine if this vascularized matrix can support an overlying skin graft as a prefabricated flap.
Main Methods:
- A vascular induction technique using epigastric pedicles in rats.
- Vascularization of standard and laser-treated Permacol of varying thicknesses.
- Assessment of skin graft viability and matrix vascularity.
Main Results:
- Vascularized Permacol flaps supported skin grafts as early as 2 weeks post-implantation.
- Laser-treated Permacol showed increased vascularity compared to standard Permacol.
- No degradation of the Permacol matrix was observed.
Conclusions:
- Permacol can be successfully vascularized and used to create tissue-engineered flaps.
- Laser treatment enhances vascularity in Permacol scaffolds.
- This matrix shows potential for use in reconstructive surgery.
