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Mutations in genes for acetylcholinesterase intensify lethality by acrylamide in Caenorhabditis elegans
Y Kamiya1, S Harada, H Yamamoto
1Department of Biochemistry, School of Medicine, Kanazawa University, Ishikawa, Japan.
Neuroscience Letters
|September 28, 1992
Abstract:
Acrylamide inhibits growth and results in death in the nematode Caenorhabditis elegans. The lethargic effect is marked in the mutants defective in genes for acetylcholinesterase (AChE) and the effect is approximately parallel with the decrease in AChE activity by mutations. Although neither the activity nor the localization of the enzyme is affected by acrylamide, the acetylcholine level was significantly elevated.