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Related Experiment Videos

Short-term memory dysfunction in Kleine-Levin syndrome.

A-M Landtblom1, N Dige, K Schwerdt

  • 1Department of Neuroscience and Locomotion, Division of Neurology, Linköping University Hospital, Linköping, Sweden. anne-marie.landtblom@lio.se

Acta Neurologica Scandinavica
|November 18, 2003
PubMed
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Kleine-Levin syndrome patients consistently show short-term memory deficits, even years after symptom recovery. Temporal lobe dysfunction may underlie these persistent cognitive impairments in Kleine-Levin syndrome.

Area of Science:

  • Neurology
  • Neuroscience
  • Neuropsychology

Background:

  • Kleine-Levin syndrome (KLS) is a rare neurological disorder.
  • Previous studies indicated long-term memory deficits and temporal lobe hypoperfusion in KLS patients.

Purpose of the Study:

  • To investigate cognitive function and cerebral perfusion in adolescent KLS patients.

Main Methods:

  • Four adolescent KLS cases were studied.
  • Neuropsychological testing and single photon emission tomography (SPECT) were utilized.
  • Previous case data was incorporated.

Main Results:

  • All four patients exhibited reduced short-term memory capacity during remission.
  • SPECT revealed temporal lobe and fronto-temporal hypoperfusion in two patients.

Related Experiment Videos

  • Two patients showed normal SPECT findings.

    • Conclusions:

    • Short-term memory dysfunction is a consistent finding in KLS.
    • Progressive memory impairment was observed in one patient.
    • Temporal lobe pathology is suggested in KLS.