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Updated: Aug 12, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Pustular generalized perforating granuloma annulare
R Gamo Villegas1, J Sopena Barona, A Guerra Tapia
1Department of Dermatology, Hospital 12 de Octubre, Avda de Andalucía Km 5.400, 28041 Madrid, Spain. reyesgamo@vodafone.es
Abstract:
We report a 84-year-old man with a 13-year history of recurrent generalized asymptomatic pustular lesions. Histology revealed areas of necrobiosis surrounded by palisading granulomas and transepidermal and follicular elimination of the necrobiotic material. A dense infiltrate of neutrophils was also found. Although 26% of patients with generalized perforating granuloma annulare have some yellow pustule-like papules, these correspond histologically to the yellow viscous necrobiotic material extruding through the epidermis and not to a real neutrophilic infiltrate. This is the first case report of perforating granuloma annulare with recurrent generalized pustular lesions with a dense infiltrate of neutrophils.
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