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Multiple trichoepitheliomas in a mother and daughter
Kerry Crotty1, Bishnu Dutta, Peter Hogan
1The Childrens Hospital at Westmead, Westmead, New South Wales, Australia.
The Australasian Journal of Dermatology
|November 18, 2003
Summary
Multiple facial papules in a mother and daughter were diagnosed as trichoepitheliomas. This autosomal dominant condition, linked to chromosome 9p21, typically appears in childhood.
Area of Science:
- Dermatology
- Genetics
Background:
- Trichoepitheliomas are benign skin tumors originating from hair follicle structures.
- Multiple trichoepitheliomas can be inherited in an autosomal dominant pattern.
Observation:
- A 38-year-old mother and her 8-year-old daughter presented with multiple facial papules that began in early childhood.
- Biopsy confirmed trichoepithelioma in the mother's lesions.
Findings:
- The familial occurrence suggests a genetic basis for the trichoepitheliomas.
- Genetic mapping has localized multiple trichoepitheliomas to chromosome 9p21.
Implications:
- While typically benign and asymptomatic, rare associations with systemic conditions warrant consideration.
- Understanding the genetic underpinnings aids in diagnosis and genetic counseling for affected families.