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Pretreatment with intravenous ketamine reduces propofol injection pain

E Barbi1, F Marchetti, T Gerarduzzi

  • 1Clinica Pediatrica U.O. di Anestesia e Rianimazione, IRCCS 'Burlo Garofolo', Università di Trieste, Italy. ebarbi@libero.it

Paediatric Anaesthesia
|November 18, 2003
PubMed

Insights

Pretreating children with ketamine before propofol sedation significantly reduces infusion line pain. This finding offers a promising strategy to improve procedural comfort for pediatric patients undergoing sedation.

Area of Science:

  • Pediatric Anesthesiology
  • Pharmacology
  • Pain Management

Background:

  • Propofol is a widely used sedative in pediatric procedural sedation.
  • Injection site pain during propofol sedation is a common and distressing issue for children.
  • Ketamine possesses analgesic properties that may mitigate propofol infusion pain.

Purpose of the Study:

  • To evaluate the efficacy of ketamine pretreatment in reducing infusion line pain during propofol sedation in children.
  • To investigate a novel approach to enhance pediatric procedural sedation safety and comfort.

Main Methods:

  • A prospective, randomized, double-blind trial was conducted with 122 pediatric patients undergoing gastroscopy.
  • Participants were randomized to receive either ketamine or saline as a pretreatment before propofol infusion.
  • Pain associated with the infusion line was the primary outcome measure.

Main Results:

  • The incidence of infusion line pain was significantly lower in the ketamine pretreatment group (8%) compared to the control group (37%).
  • P-value of 0.0001 indicates a statistically significant difference in pain incidence.

Conclusions:

  • Ketamine pretreatment (0.5 mg/kg) is highly effective in preventing propofol infusion pain in pediatric patients.
  • This strategy offers a safe and effective method to improve the experience of children undergoing procedural sedation.
Abstract

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