Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effector mechanisms in transplant rejection.

Paulo N Rocha1, Troy J Plumb, Steven D Crowley

  • 1Duke University and Durham VA Medical Centers, Durham, NC 27705, USA.

Immunological Reviews
|November 18, 2003
PubMed
Summary

Allograft rejection occurs when donor antigens activate T cells, leading to immune responses that damage the graft. Understanding these effector pathways is crucial for preventing transplant rejection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pressure in Practice: A New Clinical Case Series in <i>Hypertension</i>.

Hypertension (Dallas, Tex. : 1979)·2026
Same author

Shedding light on the role of extracellular vesicles in renal fibrosis.

Fundamental research·2026
Same author

Urinary Branched-Chain Amino Acid Excretion and Chronic Kidney Disease Progression in Patients With Type 2 Diabetes.

Diabetes·2025
Same author

The KLF4/Galectin-3 cascade is a key determinant of tubular cell death and acute kidney injury.

International journal of biological sciences·2025
Same author

Targeting PARylated RACK1/HIF-1<i>α</i> axis: A novel mechanism in acute kidney injury and therapeutic promise.

Acta pharmaceutica Sinica. B·2025
Same author

Beyond lipids: fenofibrate in diabetic retinopathy and nephropathy.

Trends in pharmacological sciences·2025

Area of Science:

  • Immunology
  • Transplantation Biology

Background:

  • Allograft rejection is a significant clinical challenge in transplantation.
  • Immune responses to donor antigens are the primary drivers of graft rejection.

Purpose of the Study:

  • To review the major effector pathways involved in allograft rejection.
  • To elucidate the role of T cells, B cells, and antibodies in graft injury.

Main Methods:

  • This review synthesizes current knowledge on immune mechanisms in allograft rejection.
  • Focuses on the functions of CD8+ cytotoxic T lymphocytes and CD4+ T helper cells.
  • Examines the contribution of alloantibodies and complement activation.

Main Results:

  • Donor-specific CD8+ cytotoxic T lymphocytes directly mediate graft injury.

Related Experiment Videos

  • CD4+ T cells orchestrate delayed-type hypersensitivity and support B-cell antibody production.
  • Alloantibodies contribute to rejection via complement activation and antibody-dependent cell-mediated cytotoxicity.

    • Conclusions:

    • Multiple immune effector pathways, including T cell responses and alloantibody production, are critical in allograft rejection.
    • Targeting these pathways offers potential strategies for preventing transplant rejection.
    • Further understanding of these mechanisms is vital for improving transplant outcomes.