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Helicobacter pylori and extragastric diseases -- other helicobacters

Antonio Gasbarrini1, Emilia Carloni, Giovanni Gasbarrini

  • 1Istituti di Patologia Medica e Medicina Interna, Universita Cattolica, Rome 00168, Italy. angiologia@rm.unicatt.it

Helicobacter
|November 18, 2003
PubMed

Insights

Helicobacter pylori infection is increasingly linked to extragastric diseases, with potential roles in cardiovascular and hepatobiliary conditions. Further research and improved detection methods are crucial for understanding these complex associations.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Helicobacter pylori (H. pylori) infection is a known cause of gastritis and peptic ulcers.
  • Emerging evidence suggests H. pylori and other Helicobacter species may contribute to extragastric conditions.
  • The role of specific strains, like CagA-positive H. pylori, is under investigation for various diseases.

Purpose of the Study:

  • To review the expanding role of Helicobacter pylori and related species in extragastric diseases.
  • To highlight the potential involvement of these bacteria in cardiovascular and hepatobiliary conditions.
  • To discuss advancements in Helicobacter detection and the use of animal models.

Main Methods:

  • Literature review of studies investigating H. pylori and extragastric diseases.
  • Analysis of evidence linking H. pylori, particularly CagA-positive strains, to cardiovascular diseases like stroke.
  • Examination of research on enterohepatic helicobacters in hepatobiliary diseases.
  • Overview of newly identified Helicobacter species and molecular detection techniques.
  • Discussion of Helicobacter felis as a model organism.

Main Results:

  • While definitive proof is often lacking, H. pylori is implicated in several extragastric diseases, notably hematologic conditions.
  • CagA-positive H. pylori strains may play a role in cardiovascular diseases, including stroke.
  • Enterohepatic helicobacters, beyond H. pylori, are increasingly recognized for their involvement in hepatobiliary diseases.
  • New Helicobacter species are continually being discovered, necessitating improved diagnostic tools.

Conclusions:

  • The association between H. pylori infection and extragastric manifestations is a growing area of research.
  • Further investigation is required to establish causal links and understand the mechanisms involved.
  • Advancements in molecular methods are essential for accurate diagnosis and the study of diverse Helicobacter species.

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