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Related Experiment Videos

Pregnancy at 40 and over: a case-control study in a developing country.

D S Weerasekera1, Surani G Udugama

  • 1Department of Obstetrics and Gynaecology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka. deepalsenaka@yahoo.co.uk

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
|November 18, 2003
PubMed
Summary

Pregnancy after 40 is linked to higher rates of gestational diabetes, pregnancy-induced hypertension, and cesarean sections compared to younger women. However, risks for premature delivery, low birth weight, and congenital anomalies remain similar.

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Reproductive Health

Background:

  • Advanced maternal age (40 years and over) is increasingly common.
  • Pregnancy outcomes in older women require careful evaluation compared to younger cohorts.

Purpose of the Study:

  • To compare obstetric and neonatal outcomes in pregnancies at or after 40 years of age versus those under 40.
  • To identify specific risks associated with advanced maternal age pregnancies.

Main Methods:

  • Retrospective cohort study comparing 150 women aged 40+ with 150 women under 40.
  • Data collected at Colombo South Teaching Hospital, Sri Lanka, between September 2001 and December 2002.
  • Outcomes analyzed included gestational diabetes, pregnancy-induced hypertension, delivery mode, birth weight, and neonatal indicators.

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Main Results:

  • Higher incidence of gestational diabetes mellitus (14.6% vs. 6.6%) and pregnancy-induced hypertension (27.3% vs. 12%) in women aged 40+.
  • Increased rates of both emergency and elective cesarean sections in the older group (48.7% vs. 20% and 21.3% vs. 14.7%).
  • No significant differences observed in premature deliveries, birth weight, 5-minute Apgar scores, or congenital anomaly rates.

Conclusions:

  • Pregnancy at advanced maternal age is associated with increased risks of specific maternal complications and cesarean delivery.
  • Neonatal outcomes such as birth weight and Apgar scores are not significantly affected by advanced maternal age in this cohort.
  • While certain risks are elevated, many key neonatal outcomes remain comparable, suggesting careful management can mitigate some advanced maternal age risks.