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[Fever as periodic disorder].

S Castelli¹, R Domenici, C Meossi

¹U.O. Pediatria Presidio Ospedaliero, USL 6, Lucca.

La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics

|July 1, 1992

Summary

Fever can be a key symptom of periodic syndromes originating in the hypothalamus. This study reviews 16 cases, highlighting temperature dysregulation as a primary indicator.

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Area of Science:

Neurology
Pediatrics
Internal Medicine

Background:

Periodic syndromes, often linked to hypothalamic dysfunction, can manifest with diverse symptoms including fever, headache, and abdominal pain.
Fever as a primary symptom of periodic syndromes is frequently overlooked or underestimated, with limited statistical data available.
Understanding the hypothalamic centers' role in temperature regulation is crucial for diagnosing periodic syndromes.

Observation:

The study presents 16 case reports where fever was a prominent, recurring symptom.
These cases involved various periodic syndromes with hypothalamic involvement.
Common etiological factors were observed across hyperthermia and other clinical signs like migraine.

Findings:

Elevated body temperature, ranging from slight to high rises, can indicate periodic syndromes originating from hypothalamic centers.
Periodic fever, alongside symptoms like headache, abdominal pain, and dizziness, suggests a potential hypothalamic-mediated periodic syndrome.
While hyperthermia and pain share common mechanisms in periodic syndromes, temperature dysregulation is the predominant feature in fever-predominant cases.

Implications:

Recognizing fever as a significant symptom of periodic syndromes can lead to earlier diagnosis and intervention.
Further research into the specific mechanisms of hypothalamic-driven periodic syndromes is warranted.
This study emphasizes the need to consider periodic fever in differential diagnoses, particularly when accompanied by other neurological or gastrointestinal symptoms.

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