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[A comparative study of 3 different types of trivalent measles-mumps-rubella vaccine]
I Contardi1, C Lusardi, G G Cattaneo
1Divisione di Pediatria, Civico Ospedale di Codogno, Milano, Italia.
Insights
A new measles, mumps, and rubella (MMR) vaccine showed excellent tolerance in children. This triple vaccine demonstrated fewer side effects and fever episodes, suggesting a more attenuated measles strain.
Area of Science:
- Immunology
- Pediatrics
- Vaccinology
Background:
- Measles, mumps, and rubella (MMR) are common childhood viral infections.
- Vaccination is crucial for preventing these diseases and their complications.
- Comparative studies are essential to evaluate the safety and efficacy of different vaccine formulations.
Purpose of the Study:
- To compare the tolerability of three different triple vaccines against measles, mumps, and rubella.
- To assess the incidence and severity of side effects, including fever, in children receiving the vaccines.
Main Methods:
- A randomized, double-blind, comparative clinical trial was conducted.
- 201 children (101 males, 100 females) aged 15 months to 14 years participated.
- Participants received one of three types of MMR triple vaccine.
Main Results:
- The vaccine containing Edmonston-Zagreb, Rubini, and Wistar Ra 27/3 strains was well-tolerated.
- This specific vaccine exhibited a lower incidence of side effects and fever attacks.
- Fever was the most frequent symptom, particularly in children aged 2-5 years.
Conclusions:
- The MMR vaccine with Edmonston-Zagreb, Rubini, and Wistar Ra 27/3 strains demonstrates superior tolerability.
- The enhanced tolerance is likely attributed to a more attenuated measles strain.
- This finding supports the use of this specific vaccine formulation for improved pediatric immunization outcomes.
Abstract:
The results of a randomized double blind comparative clinical trial are described. 201 children, 101 males and 100 females, average age 3.11 +/- 1.1 (range 15 months to 14 years) received 3 different types of triple vaccine against measles, mumps and rubella. The vaccine containing the strains Edmonston-Zagreb, Rubini and Wistar Ra 27/3 was well tolerated both for the number of side-effects and for the number and the level of the fever attacks, that resulted the most frequent symptom, especially in the children from 2 to 5 years. The differences between side effects were highly significant. In accordance with the obtained results and considering the data of other studies, the Authors conclude that the principal reason of this tolerance is due to more attenuated strain against measles.