RecQ helicases and topoisomerase III in cancer and aging

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Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System
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Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System

Published on: March 18, 2010

Louise V Laursen1, Lotte Bjergbaek, Johanne M Murray

  • 1Department of Molecular Biology, Aarhus University, C.F. Møllers Allé, Bldg. 130, 8000 Aarhus-C, Denmark.

Biogerontology
|November 18, 2003
PubMed

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Homologous Recombination

The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
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