Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The biofilm matrix.

David G Allison1

  • 1School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, UK, david.allison@man.ac.uk

Biofouling
|November 19, 2003
PubMed
Summary
This summary is machine-generated.

The extracellular matrix (ECM) provides structure and stability to biofilms. Its complex composition and interactions with environmental factors create a dynamic microenvironment for cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementation of the national antimicrobial stewardship competencies for UK undergraduate healthcare professional education within undergraduate pharmacy programmes: a survey of UK schools of pharmacy.

JAC-antimicrobial resistance·2023
Same author

Teacher and Student Views on the Feasibility of Peer to Peer Education as a Model to Educate 16-18 Year Olds on Prudent Antibiotic Use-A Qualitative Study.

Antibiotics (Basel, Switzerland)·2020
Same author

Peer-Education as a Tool to Educate on Antibiotics, Resistance and Use in 16-18-Year-Olds: A Feasibility Study.

Antibiotics (Basel, Switzerland)·2020
Same author

Antibiotic resistance awareness: a public engagement approach for all pharmacists.

The International journal of pharmacy practice·2016
Same author

Enhancement of the properties of a drug by mono-deuteriation: reduction of acid-catalysed formation of a gut-motilide enol ether from 8-deuterio-erythromycin B.

Organic & biomolecular chemistry·2016
Same author

Influence of gentamicin and tobramycin on binary biofilm formation by co-cultures of Burkholderia cepacia and Pseudomonas aeruginosa.

Journal of basic microbiology·2005
Same journal

Natural deep eutectic solvents as environmentally compatible agents for biofilm inhibition and disruption.

Biofouling·2026
Same journal

Antifungal activity of chrysin against <i>Candida albicans</i> biofilms In <i>vitro</i> and In <i>vivo</i>.

Biofouling·2026
Same journal

Assessing the impacts of varying UVC doses on a silicone fouling release coating.

Biofouling·2026
Same journal

Chemical fingerprints of <i>Lamiaceae</i> essential oils: targeting biofilm viability, biomass, metabolic activity, and membrane integrity.

Biofouling·2026
Same journal

Antibiofilm activity of berberine against <i>Staphylococcus aureus</i>.

Biofouling·2026
Same journal

Phenotypic switch <i>Candidozyma auris</i> (<i>Candida auris</i>) modulates biofilm formation and virulence genes <i>SAP5</i> and <i>ALS5</i> in mono- and co-culture environments with <i>Staphylococcus aureus</i>.

Biofouling·2026
See all related articles

Area of Science:

  • Microbiology
  • Biochemistry
  • Materials Science

Background:

  • The extracellular matrix (ECM) is crucial for biofilm architecture and stability.
  • Biofilm ECM comprises cells, water, secreted macromolecules, and enzymatic activities.
  • The ECM's structure is influenced by both internal components and external factors.

Purpose of the Study:

  • To elucidate the composition and functional significance of the extracellular matrix in biofilms.
  • To explore the dynamic interactions within the biofilm matrix.
  • To understand how intrinsic and extrinsic factors shape the biofilm microenvironment.

Main Methods:

  • Literature review on biofilm ECM composition and function.
  • Analysis of molecular interactions within the matrix.

Related Experiment Videos

  • Investigation of environmental influences on matrix architecture.

    • Main Results:

    • The ECM is a heterogeneous consortium of components and activities.
    • Intrinsic interactions create diverse local environments within the matrix.
    • Extrinsic factors like nutrient levels and fluid shear modulate ECM structure.

    Conclusions:

    • The biofilm extracellular matrix is a dynamic, multifunctional entity.
    • Its complex nature supports a heterogeneous microenvironment essential for biofilm survival.
    • Understanding the ECM is key to controlling biofilm formation and function.