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Updated: Aug 30, 2026

Observing and Quantifying Fibroblast-mediated Fibrin Gel Compaction
Published on: January 16, 2014
One-dimensional viscoelastic behavior of fibroblast populated collagen matrices
Jessica E Wagenseil1, Tetsuro Wakatsuki, Ruth J Okamoto
1Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S. Euclid, CB 8228, St. Louis, MO 63110, USA. Jessica.Wagenseil@cellbio.wustl.edu
Abstract:
Bio-artificial tissues are being developed as replacements for damaged biologic tissues. Their mechanical properties are critical for load bearing applications. Current testing protocols for bio-artificial tissues vary widely and often do not consider viscoelasticity. Uniaxial stretch tests were performed on fibroblast populated collagen matrices (FPCMs) to determine the influence of specific test protocols on the mechanical behavior. The peak force, hysteresis and shape of the force-stretch curve are affected by the stretch rate, rest period, stretch amplitude and the number and magnitude of preconditioning cycles.
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