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Related Experiment Videos

Is Anisakis simplex responsible for chronic urticaria?

Maria Pilar López-Sáez1, J M Zubeldia, M Caloto

  • 1Allergy Department, Hospital General Universitario Gregorio Marañón, Servicio de Alergia, Dr. Esquerdo 46, 28007 Madrid, Spain.

Allergy and Asthma Proceedings
|November 19, 2003
PubMed
Summary
This summary is machine-generated.

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Sensitization to the parasite Anisakis simplex is common in chronic urticaria (CU) patients, but a direct causal link to CU remains undetermined. This elevated sensitization may cross-react with other parasites.

Area of Science:

  • Immunology
  • Parasitology
  • Dermatology

Background:

  • Chronic urticaria (CU) association with parasitic infestations is understudied.
  • Anisakis simplex sensitization is linked to acute urticaria and anaphylaxis.

Purpose of the Study:

  • To investigate the relationship between Anisakis simplex sensitization and chronic urticaria.
  • To determine if Anisakis simplex sensitization causes or exacerbates CU.

Main Methods:

  • 101 CU patients studied for Anisakis simplex sensitization via skin prick tests and specific IgE (CAP).
  • Assessed IgE to other parasites (Ascaris lumbricoides, Echinococcus granulosus, Toxocara canis).
  • Dietary interventions (fish/seafood restriction) and clinical follow-up at 6, 12, and 18 months.

Related Experiment Videos

Main Results:

  • 55% of CU patients showed positive CAP to Anisakis simplex; 35% had positive skin tests.
  • Elevated Anisakis simplex sensitization was observed, with cross-reactivity to other parasites.
  • No causal relationship found between Anisakis simplex sensitization and CU development or clinical course.

Conclusions:

  • High prevalence of Anisakis simplex sensitization in CU patients, potentially due to cross-reactivity.
  • No causal link established between Anisakis simplex specific IgE and chronic urticaria.
  • Clinical significance of Anisakis simplex sensitization in CU requires further investigation.