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Thyroid dysfunction and their relation to cardiovascular risk factors such as lipid profile, hsCRP, and waist hip

Chan Hee Jung1, Ki Chul Sung, Hun Sub Shin

  • 1Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine, Pyung-dong, Jongro-gu, Seoul.

The Korean Journal of Internal Medicine
|November 19, 2003
PubMed

Insights

Thyroid dysfunction, including subclinical hypothyroidism, is linked to cardiovascular risks and elevated cholesterol levels. Early screening and treatment for subclinical hypothyroidism are recommended due to its impact on lipid metabolism.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Public Health

Background:

  • Thyroid abnormalities are common and linked to cardiovascular disease (CVD) and dyslipidemia.
  • Overt and subclinical hypothyroidism increase CVD risk.
  • Investigated prevalence and cardiovascular risk factor associations of thyroid disorders.

Purpose of the Study:

  • Determine the prevalence of overt and subclinical thyroid disorders.
  • Examine associations between thyroid dysfunction and cardiovascular risk factors.
  • Evaluate the clinical significance of subclinical hypothyroidism.

Main Methods:

  • Large-scale study of 66,260 subjects (aged 20-80).
  • Measured serum free thyroxine (FT4), TSH, total cholesterol, LDL-C, HDL-C, and hsCRP.
  • Utilized radioimmunoassay (RIA) and nephelometry for analyses.

Main Results:

  • Prevalence rates: overt thyrotoxicosis (0.5%), subclinical thyrotoxicosis (0.64%), overt hypothyroidism (0.16%), subclinical hypothyroidism (0.64%).
  • Hypothyroidism (overt and subclinical) showed elevated total cholesterol and LDL-C compared to controls.
  • Hypothyroidism associated with higher waist-to-hip ratio; overt thyrotoxicosis with lower.

Conclusions:

  • Thyroid dysfunction prevalence in Korea is comparable globally, age-dependent, and higher in women.
  • Hypothyroidism linked to increased obesity index (waist-to-hip ratio).
  • Subclinical hypothyroidism is associated with adverse atherogenic parameters, warranting screening and treatment for lipid metabolism effects.
Abstract

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