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Published on: January 28, 2020
An elevated value of C-reactive protein is the only predictive factor of restenosis after percutaneous coronary
Woo Kon Jeong1, Myung Ho Jeong, Kye Hun Kim
1Cardiac Catheterization Laboratory, Heart Center of Chonnam National University Hospital, Hakdong 8, Dong-gu, Gwangju, 501-757, Korea.
Insights
C-reactive protein (CRP) levels are a key indicator for restenosis after percutaneous coronary interventions (PCI). Elevated CRP significantly predicts restenosis, highlighting its importance in cardiovascular disease management.
Area of Science:
- Cardiology
- Biomarkers
- Inflammation
Background:
- Percutaneous coronary interventions (PCI) are limited by restenosis.
- Inflammation is implicated in cardiovascular disease pathogenesis.
Purpose of the Study:
- To prospectively evaluate inflammatory markers as predictors of restenosis after PCI.
- To compare seropositivity and C-reactive protein (CRP) levels in patients with and without restenosis.
Main Methods:
- 272 patients with coronary artery disease undergoing PCI were studied.
- Patients were divided into groups based on restenosis occurrence.
- IgG seropositivity, CMV titers, C. pneumoniae, H. pylori, and CRP levels were compared.
Main Results:
- No significant differences in IgG seropositivity for CMV, C. pneumoniae, or H. pylori were found.
- Low Thrombolysis in Myocardial Infarction (TIMI) flow was more common in the restenosis group.
- Elevated CRP levels (> 0.5 mg/dL) and higher CRP values were significantly associated with restenosis (p = 0.001).
Conclusions:
- C-reactive protein (CRP) is the most significant predictor of restenosis following PCI.
- Inflammatory marker assessment, particularly CRP, is crucial for predicting PCI outcomes.
Background:
The current techniques for percutaneous coronary interventions (PCI) remain limited by restenosis. Recent studies have provided evidence of inflammation playing a role in the pathogenesis of cardiovascular disease.
Methods:
Whether inflammatory markers are predictors of subsequent restenosis were prospectively tested in 272 consecutive patients with angiographically proven coronary artery disease. Patients having undergone PCI at Chonnam National University Hospital, between Sept. 1999 and Mar. 2001, were divided into two groups according to the occurrence of restenosis on a follow-up coronary angiogram: Group I were patients with restenosis (n = 99, 59.5 +/- 10.8 years, M:F = 77:22) and Group II were those without restenosis (n = 173, 58.8 +/- 10.2 years, M:F = 131:42). The IgG seropositivity, cytomegalovirus (CMV) titers, C. pneumoniae. H. pylori and levels of C-reactive protein (CRP) were compared between the two groups.
Results:
There were no statistical differences in the seropositivity of the CMV IgG C. pneumoniae IgG and H. pylori IgG between the two groups (Groups I vs. II: 100 vs. 100%, 24.7 vs. 25.7% and 62.2 vs. 63.7%, respectively). Of the angiographic parameters, a low Thrombolysis in Myocardial Infarction (TIMI) flow (TIMI 0 or 1) was more common in Group I than Group II (p = 0.038). The patients with an elevated CRP (> 0.5 mg/dL) were more common in Group I than Group II (57.6 vs. 36.4%, p = 0.001), with the CRP values being higher in Group I than Group II (3.3 +/- 5.8 vs. 1.3 +/- 2.6 mg/dL, p = 0.001). According to a multiple logistic regression analysis, the CRP was the only predictor of restenosis, with an odds ratio of 2.1169 (95% C.I. 1.2062-3.7154, p = 0.009).
Conclusion:
The CRP value is the most important predictor of restenosis after PCI.
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