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[Effect of cimetidine with chemotherapy on stage IV colorectal cancer]
Kazuhiko Yoshimatsu1, Keiichiro Ishibashi, Masahiko Hashimoto
1Dept. of Surgery, Tokyo Women's Medical University Daini Hospital.
Abstract:
We herein report the result of a prospective study to investigate the efficacy of cimetidine administration in conjunction with chemotherapy for stage IV colorectal cancer. Sixty-two patients treated with Leucovorin/5-fluorouracil therapy were enrolled from 1996 to 2000. Both groups were well matched for pre-treatment characteristics. There was no difference in survival in cur B patients. However, the cimetidine group had significantly prolonged survival in the patients with cur C or non-resectable carcinoma. This study suggests that cimetidine treatment may improve the survival of patients with non-curative surgery for stage IV colorectal cancer.
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