Related Experiment Video
Updated: Jul 13, 2026
06:39
Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
Published on: August 18, 2016
[Homocysteine as a coronary risk factor]
Voprosy Pitaniia
|November 19, 2003
Summary
High blood homocysteine levels increase atherosclerosis risk. This review explores soy products, folate, and vitamins B6/B12 for homocysteine-reducing therapy in cardiovascular disease patients.
Area of Science:
- Biochemistry and Molecular Biology
- Cardiovascular Medicine
- Nutritional Science
Context:
- Numerous clinical and epidemiological trials link elevated blood homocysteine to increased risk of coronary, cerebral, and peripheral atherosclerosis.
- The homocysteine theory of atherosclerosis is supported by its pro-oxidant actions, enhancement of platelet aggregation, and inhibition of endothelial cell growth.
- Cardiovascular diseases remain a leading cause of mortality worldwide, necessitating research into novel therapeutic targets and strategies.
Purpose:
- To review the role of homocysteine as a risk marker for atherosclerosis.
- To explore the potential of homocysteine-reducing therapies, including soy products, folate, and vitamins B6 and B12, for managing cardiovascular diseases.
- To synthesize current evidence on the homocysteine theory of atherosclerosis and its therapeutic implications.
Summary:
- High blood homocysteine levels are established markers for increased risk of atherosclerosis across multiple vascular beds.
- Mechanisms linking homocysteine to atherosclerosis include pro-oxidant effects, platelet hyper-reactivity, and impaired endothelial cell function.
- Dietary interventions, specifically soy products, folate, and vitamins B6/B12, are proposed as therapeutic strategies to lower homocysteine and mitigate cardiovascular risk.
Impact:
- Provides a comprehensive overview of the homocysteine theory of atherosclerosis, consolidating evidence from clinical and epidemiological studies.
- Highlights the therapeutic potential of readily available nutritional interventions for cardiovascular disease prevention and management.
- Informs healthcare professionals and researchers about homocysteine as a modifiable risk factor and potential therapeutic target in cardiovascular medicine.
More Related Videos
07:29Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
10:03Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
01:26Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
01:30Coronary Artery Disease III: Clinical Manifestations
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
01:26Coronary Artery Disease IV: Preventive Measures
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
01:30Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...