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Updated: Jul 27, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
[Systemic lupus erythematous and pregnancy].
Radamés Rivas-López1, Rafael Buitrón García-Figueroa, Raúl Romero-Cabello
1Servicio de Ginecología y Obstetricia, Hospital General de México O.D.
Ginecologia Y Obstetricia De Mexico
|November 19, 2003
Summary
Pregnancy outcomes for patients with systemic lupus erythematosus (SLE) show reduced risks with inactive disease. However, preterm birth and intrauterine growth restriction remain concerns, necessitating multidisciplinary care.
Area of Science:
- Obstetrics and Gynecology
- Rheumatology
- Maternal-Fetal Medicine
Context:
- Systemic lupus erythematosus (SLE) presents unique challenges during pregnancy.
- Maternal and fetal outcomes require careful monitoring and management.
- Previous research highlights risks associated with SLE in pregnancy.
Purpose:
- To evaluate the obstetrics outcomes in pregnant patients diagnosed with systemic lupus erythematosus (SLE).
- To identify maternal complications and fetal outcomes in this high-risk obstetric population.
- To assess the impact of disease activity and co-existing conditions on pregnancy.
Summary:
- A retrospective study reviewed 36 cases of pregnancy in SLE patients.
- Hypertensive disorders were the most frequent maternal complication (27.5%).
- One patient with antiphospholipid syndrome and HELLP syndrome died due to brain hemorrhage.
Impact:
- Pregnancies in SLE patients are high-risk, requiring multidisciplinary management.
- Inactive SLE disease correlates with decreased maternal-fetal morbidity and mortality.
- Antiphospholipid syndrome significantly worsens pregnancy prognosis, increasing risks of complications and adverse outcomes.
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