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Related Experiment Videos

Multi-pulse drug delivery from a resorbable polymeric microchip device.

Amy C Richards Grayson1, Insung S Choi, Betty M Tyler

  • 1Deaprtment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA.

Nature Materials
|November 19, 2003
PubMed
Summary
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Biodegradable microchips offer controlled, multi-dose drug delivery for chronic conditions. These devices successfully released multiple drug pulses, maintaining drug bioactivity for long-term pulsatile therapy.

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Polymer Science

Background:

  • Controlled-release drug delivery systems are crucial for managing chronic conditions like hormone deficiencies and pain.
  • Pulsatile drug release is often required for effective long-term treatment, necessitating advanced delivery systems.
  • Existing systems may lack the capacity for multi-dose or precisely timed pulsatile release.

Purpose of the Study:

  • To develop and evaluate biodegradable polymeric microchips for multi-dose, pulsatile drug delivery.
  • To assess the in vitro release profiles and bioactivity of drugs delivered via these microchips.
  • To demonstrate the potential for customizable drug release intervals using varying membrane properties.

Main Methods:

  • Fabrication of biodegradable microchips (1.2 cm diameter, 480-560 µm thick) from poly(L-lactic acid).

Related Experiment Videos

  • Incorporation of 36 reservoirs per microchip, each capable of holding different substances.
  • Use of poly(D,L-lactic-co-glycolic acid) membranes with varying molecular masses to control drug release.
  • In vitro release studies using radiolabelled dextran, human growth hormone, and heparin.

    • Main Results:

    • Successful fabrication of microchips capable of delivering four distinct pulses of model drugs.
    • Sustained release of heparin over 142 days with an average retained bioactivity of 96 ± 12%.
    • Demonstrated potential for differential drug release by varying membrane composition and molecular weight.

    Conclusions:

    • Biodegradable polymeric microchips represent a promising platform for multi-dose, pulsatile drug delivery.
    • The system allows for controlled release of various therapeutic agents, maintaining their bioactivity.
    • Customizable membrane properties offer a pathway to achieving specific drug release profiles for tailored patient treatment.