Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytokine cascade in sepsis.

Jean-Marc Cavaillon1, Minou Adib-Conquy, Catherine Fitting

  • 1UP Cytokine and Inflammation, Institut Pasteur, Paris, France. jmcavail@pasteur.fr

Scandinavian Journal of Infectious Diseases
|November 19, 2003
PubMed
Summary

Sepsis triggers excessive pro- and anti-inflammatory cytokines, signaling poor outcomes. Low levels of the chemokine RANTES correlate with worse sepsis prognosis, indicating its protective role.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hyperlactatemia in sepsis and shock: a renal metabolic perspective.

Critical care (London, England)·2026
Same author

Immunogenicity of PCV13 during Hospitalization soon after infection resolution: Vaccis study.

NPJ vaccines·2026
Same author

Sodium oxybate versus midazolam for end-of-life continuous deep sedation: a randomised controlled trial.

BMJ supportive & palliative care·2025
Same author

Self-extubation in critically ill patients: from the French OUTCOMEREA Network.

Critical care (London, England)·2025
Same author

Beyond inflammation: the role of metabolic dysregulation in sepsis diagnosis and treatment.

Intensive care medicine·2025
Same author

Sepsis in patients who are immunocompromised: diagnostic challenges and future therapies.

The Lancet. Respiratory medicine·2025

Area of Science:

  • Immunology
  • Critical Care Medicine

Background:

  • Sepsis involves dysregulated cytokine production, impacting patient outcomes.
  • Cytokines exhibit dual roles, essential for infection control but detrimental when overproduced.

Purpose of the Study:

  • To investigate the complex interplay of cytokines during sepsis.
  • To identify cytokine profiles associated with sepsis severity and patient survival.

Main Methods:

  • Analysis of pro- and anti-inflammatory cytokine levels in patient plasma.
  • Correlation analysis between cytokine levels, APACHE II scores, and patient outcomes.

Main Results:

  • Elevated cytokine levels, particularly in non-survivors, indicate their role as markers and causative agents of poor outcomes.

Related Experiment Videos

  • The chemokine RANTES showed an inverse correlation with APACHE II scores (r = -0.7; p = 0.02), with low levels linked to adverse outcomes.
  • Despite high levels of anti-inflammatory cytokines and inhibitors, their capacity to fully counteract proinflammatory cytokines in sepsis remains questionable.

    • Conclusions:

    • Cytokine networks in sepsis are complex, with excessive production contributing to immunodysregulation and poor prognosis.
    • RANTES may serve as a valuable prognostic biomarker in sepsis.
    • The balance between pro- and anti-inflammatory responses is critical in sepsis, and current anti-inflammatory strategies may be insufficient.