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Related Concept Videos

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Genome-wide Association Studies-GWAS

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Rheumatic Heart Disease III: Medical Management

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Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography
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Lung involvement in rheumatoid arthritis.

Massimo Triggiani1, Francescopaolo Granata, Giorgio Giannattasio

  • 1Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy. triggian@unina.it

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases : Official Journal of WASOG
|November 19, 2003
PubMed
Summary

Rheumatoid arthritis (RA) frequently affects the lungs, even without obvious symptoms. Early lung screening in RA patients is crucial for detecting potentially life-threatening conditions.

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Area of Science:

  • Rheumatology
  • Pulmonology
  • Immunology

Background:

  • Rheumatoid arthritis (RA) is a systemic autoimmune disease predominantly affecting joints.
  • Extra-articular manifestations are common, with lung involvement being a significant concern.
  • Autopsy data indicates a higher prevalence of lung pathology in RA patients than clinically apparent.

Purpose of the Study:

  • To highlight the prevalence and significance of lung involvement in rheumatoid arthritis.
  • To emphasize the discrepancy between clinical presentation and actual lung pathology in RA.
  • To advocate for early screening and monitoring of pulmonary complications in RA patients.

Main Methods:

  • Review of existing literature on rheumatoid arthritis and associated lung diseases.
  • Analysis of autopsy findings related to RA and pulmonary pathology.
  • Discussion of clinical, radiological, and functional lung assessments in RA.

Main Results:

  • Lung alterations in RA are diverse, affecting alveoli, interstitium, airways, and pleura.
  • Pathological lung changes in RA are more common than clinically diagnosed.
  • These alterations can lead to impaired lung function and pose life-threatening risks.

Conclusions:

  • All rheumatoid arthritis patients require clinical and lung function evaluation at diagnosis and during follow-up.
  • Patients with clinical or functional lung abnormalities should undergo comprehensive radiological assessment.
  • Proactive screening and monitoring are essential for managing RA-related lung disease.