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Lipid peroxidation in bronchial asthma.
Anita Sharma1, Satish Bansal, R K Nagpal
1Department of Pediatrics, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India. dr_anitasharma@sifymail.com
Indian Journal of Pediatrics
|November 19, 2003
Summary
Children with bronchial asthma show elevated levels of free oxygen radicals, indicated by serum Malondiadehyde (MDA), during both asthma attacks and symptom-free periods. These levels decrease with treatment but remain higher than in healthy children.
Area of Science:
- Pediatric Pulmonology
- Biochemistry
- Oxidative Stress Research
Background:
- Bronchial asthma is a chronic inflammatory airway disease.
- Oxidative stress plays a role in asthma pathogenesis.
- Free oxygen radicals are implicated in inflammatory processes.
Purpose of the Study:
- To investigate free oxygen radical levels in children with bronchial asthma.
- To compare radical levels during acute attacks versus symptom-free intervals.
- To assess the impact of treatment on radical levels.
Main Methods:
- Serum Malondiadehyde (MDA) levels were measured in 25 children (6-14 years) with acute asthma.
- Measurements were taken at admission, 24-48 hours post-treatment, and after 3 weeks symptom-free.
- Results were compared to a healthy control group.
Main Results:
- Serum MDA levels were highest during acute asthma attacks.
- MDA levels significantly decreased after treatment but remained elevated.
- Elevated MDA levels persisted even during symptom-free intervals compared to controls.
Conclusions:
- Lipid peroxidation, indicated by MDA, is increased in pediatric bronchial asthma.
- Elevated oxidative stress is present during both acute exacerbations and remission phases.
- Further research into antioxidant therapies for asthma may be warranted.