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Bladder dysfunction and end stage renal disease
Dirk-Henrik Zermann1, Uwe Löffler, Olaf Reichelt
1Department of Urology, University Hospital, Friedrich-Schiller-University Jena, Germany. dh.zermann@med.uni-jena.de
International Urology and Nephrology
|November 19, 2003
Summary
Many patients with end-stage renal disease experience lower urinary tract dysfunction. Urodynamic assessment before kidney transplantation is recommended for those with voiding symptoms to prevent allograft complications.
Area of Science:
- Urology
- Nephrology
- Lower Urinary Tract Function
Background:
- End-stage renal disease (ESRD) significantly impacts overall patient health.
- Lower urinary tract symptoms (LUTS) are common in ESRD patients.
- Pre-transplant evaluation is crucial for optimizing outcomes.
Purpose of the Study:
- To evaluate lower urinary tract function in ESRD patients.
- To assess the prevalence of bladder dysfunction before renal transplantation.
- To determine the utility of urodynamic studies in this population.
Main Methods:
- A cohort of 52 ESRD patients (14 female, 38 male) underwent diagnostic work-up.
- Urodynamic studies were performed as part of the evaluation.
- Patients had various causes of renal failure, including glomerulonephritis and diabetic nephropathy.
Main Results:
- 77% of patients exhibited abnormalities in lower urinary tract function.
- Common findings included bladder hypersensitivity (31%), poor bladder compliance (38%), detrusor instability (25%), and detrusor-sphincter dyssynergia (33%).
Conclusions:
- High incidence of bladder dysfunction in ESRD patients.
- Urodynamic assessment is recommended pre-transplant for symptomatic patients to prevent allograft dysfunction.
- Post-transplant urodynamic follow-up may be necessary based on initial findings.