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Multiple risk factor clustering and risk of hypertension in Japanese male office workers

Noriyuki Nakanishi1, Wenjuan Li, Hideki Fukuda

  • 1Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, 2-2 Yamada-oka, Suita-shi, Osaka 565-0871, Japan.

Industrial Health
|November 19, 2003
PubMed

Insights

Accumulating multiple hypertension risk factors significantly elevates blood pressure and hypertension risk in Japanese men. More risk factors mean higher odds of developing hypertension.

Area of Science:

  • Cardiovascular Health
  • Epidemiology
  • Internal Medicine

Background:

  • Hypertension is a major global health concern.
  • Identifying modifiable risk factors is crucial for prevention.
  • Previous studies have explored various risk factors for hypertension.

Purpose of the Study:

  • To investigate the association between the accumulation of major risk factors and hypertension in Japanese men.
  • To quantify the increased odds of hypertension with increasing numbers of risk factors.
  • To examine the dose-dependent relationship between risk factors and blood pressure levels.

Main Methods:

  • A cross-sectional study involving 5275 Japanese male office workers aged 23-59 years.
  • Assessment of major risk factors: family history, obesity, diabetes mellitus, hypercholesterolemia, hypertriglyceridemia, hyperuricemia, and elevated white blood cell counts.
  • Statistical analysis using odds ratios and adjusted mean differences in blood pressure.

Main Results:

  • The odds ratio for hypertension increased significantly with the number of risk factors (OR=1.91 for 1 factor to OR=8.18 for >=5 factors).
  • Systolic and diastolic blood pressure levels showed a dose-dependent increase with the accumulation of risk factors.
  • Men with >=5 risk factors had significantly higher adjusted mean systolic (11.2 mmHg) and diastolic (9.2 mmHg) blood pressures compared to those with no risk factors.

Conclusions:

  • The accumulation of major risk factors is strongly associated with an increased risk of hypertension in Japanese men.
  • These findings highlight the importance of managing multiple risk factors for hypertension prevention in this population.
  • Public health strategies should focus on comprehensive risk factor management to reduce hypertension prevalence.

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