Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinical applications of tissue engineered constructs.

Evan Stuart Garfein1, Dennis P Orgill, Julian J Pribaz

  • 1Division of Plastic and Reconstructive Surgery, Brigham and Women's, Hospital, 75 Francis Street, Boston, MA 02115, USA.

Clinics in Plastic Surgery
|November 19, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: 10th anniversary of frontiers in surgery: celebrating progress and envisioning the future of multidisciplinary surgery.

Frontiers in surgery·2026
Same author

Outcomes and Challenges of Flap Reconstruction for Pressure Injuries in Clinically Complex Patients.

Journal of clinical medicine·2026
Same author

Short-Term Functional Trajectories After Surgery in Older Adults: National Patterns of Loss and Recovery in 436,471 Patients.

Annals of surgery open : perspectives of surgical history, education, and clinical approaches·2026
Same author

Artificial Intelligence-Based Risk Prediction Models for Complications After Tongue Cancer Surgery.

JAMA otolaryngology-- head & neck surgery·2026
Same author

The Utility and Applicability of the Modified 5-Item Frailty Index in Cosmetic Surgery.

Aesthetic plastic surgery·2026
Same author

Low protein, high risk: hypoalbuminemia predicts adverse outcomes after mastectomy in 37,848 breast cancer patients.

Breast cancer (Tokyo, Japan)·2026

Reconstructing soft tissue defects requires complex composites of multiple tissues. Future tissue engineering will integrate advanced techniques with stem cell biology for successful bioengineered tissue constructs.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Plastic Surgery

Background:

  • Soft tissue defect reconstruction presents significant challenges for plastic surgeons and tissue engineers.
  • Creating successful replacements necessitates a composite of endoderm, mesoderm, and ectoderm for biological, functional, and cosmetic outcomes.
  • The ideal construct must be durable, immune-competent, and integrate various tissues like bone, cartilage, muscle, and skin.

Purpose of the Study:

  • To explore the future of tissue engineering for soft tissue reconstruction.
  • To highlight the integration of current reconstructive modalities with advanced tissue engineering and stem cell biology.
  • To outline the potential for bioengineered tissue constructs in clinical applications.

Main Methods:

Related Experiment Videos

  • Combining prefabrication and pre-lamination techniques with advanced tissue engineering.
  • Utilizing stem cell biology for tissue synthesis and regeneration.
  • Developing bio-absorbable matrices for prefabrication to create well-perfused scaffolds.

    • Main Results:

    • In vitro synthesized tissues with improved structure, color, and texture can be pre-laminated.
    • Prefabrication of bio-absorbable matrices yields well-perfused scaffolds for tissue integration.
    • The convergence of these technologies promises more effective reconstructive solutions.

    Conclusions:

    • The future of soft tissue reconstruction lies in the synergistic integration of tissue engineering, stem cell biology, and current reconstructive methods.
    • Bioengineered tissue constructs offer a promising reality for addressing complex reconstructive challenges.
    • Further research, interdisciplinary collaboration, and clinical experience are crucial for advancing this field.