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The National Cancer Institute: cancer drug discovery and development program
M R Grever1, S A Schepartz, B A Chabner
1Director, Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20892.
Abstract:
The discovery and development of novel therapeutic products for the treatment of malignancy is vitally important to those physicians responsible for the management of cancer patients. A description of the ongoing efforts at the National Cancer Institute (NCI) is intended to provide insight into those complex processes necessary to accomplish this mission. An update on the NCI's revised cancer screen is accompanied by a brief summary of those new agents scheduled to be entered into clinical investigation in the near future. The tremendous potential advantages and challenges associated with the use of a molecular approach to cancer drug design are discussed. Despite the differences of opinion that may exist regarding the optimal strategies for accomplishing the mission, there is no disagreement regarding the importance of the effort to find effective new therapies for cancer patients.
Insights
The National Cancer Institute (NCI) is advancing novel cancer therapies through revised screening and molecular drug design. This research highlights ongoing efforts to discover effective treatments for cancer patients, addressing both potential and challenges.
Area of Science:
- Oncology
- Pharmacology
- Drug Discovery
Background:
- Developing new cancer treatments is crucial for patient care.
- The National Cancer Institute (NCI) plays a key role in cancer drug development.
- Understanding the complex processes involved is essential.
Purpose of the Study:
- To provide insight into the National Cancer Institute's (NCI) efforts in discovering novel therapeutic products for malignancy.
- To update on the NCI's revised cancer screening process.
- To discuss the molecular approach to cancer drug design.
Main Methods:
- Review of NCI's ongoing drug discovery and development processes.
- Summary of new agents entering clinical investigation.
- Discussion of advantages and challenges in molecular cancer drug design.
Main Results:
- The NCI is actively pursuing new therapeutic agents for cancer treatment.
- A revised cancer screening process is being implemented.
- Molecular approaches offer significant potential but also present challenges in drug design.
Conclusions:
- There is a critical need for effective new cancer therapies.
- The NCI's efforts are vital in the complex process of drug discovery.
- Collaboration and diverse strategies are important for advancing cancer treatment.