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Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
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Aging on the waiting list: should it be a further criterion for cadaver kidney allocation?

M Salvadori1, L Comparini, E Bertoni

  • 1Department of Transplantation, Careggi Hospital, Florence, Italy.

Transplant International : Official Journal of the European Society for Organ Transplantation
|January 1, 1992
PubMed

Insights

Kidney transplant selection prioritizes HLA match and patient health, leading to most patients receiving transplants within two years. Those remaining on the waitlist face declining health and reduced transplant opportunities.

Area of Science:

  • Nephrology
  • Transplantation Immunology

Background:

  • Dialysis patients are candidates for kidney transplantation.
  • Transplant selection relies on Human Leukocyte Antigen (HLA) matching and patient clinical status.

Purpose of the Study:

  • To evaluate the impact of HLA matching and clinical condition criteria on kidney transplant waitlist times.
  • To identify factors contributing to prolonged waitlist duration.

Main Methods:

  • Retrospective analysis of dialysis patients on the kidney transplant waitlist.
  • Assessment of HLA matching scores and clinical condition parameters at time of listing.

Main Results:

  • The majority of patients meeting selection criteria received transplants within two years.
  • Patients remaining on the waitlist longer experienced clinical deterioration.
  • Increased risk factors were associated with extended waitlist times.

Conclusions:

  • Current selection criteria expedite transplantation for well-matched, healthy patients.
  • Prolonged waitlist duration is linked to worsening health and increased surgical risks.
  • Alternative strategies may be needed for patients with deteriorating conditions.

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