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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Published on: May 27, 2011

CMV prophylaxis after renal transplantation with immunoglobulin or CMV-hyperimmunoglobulin--a prospective clinical

D Stippel1, P Wienand, N Weissenberg

  • 1Department of Surgery, University of Cologne, Cologne, FRG.

Transplant International : Official Journal of the European Society for Organ Transplantation
|January 1, 1992
PubMed

Three groups of 40 patients each entered this prospective randomized trial. Patients of group A received 2 ml/kg body weight CMV-Polyglobulin, patients of group B 15 g Intraglobin and patients of group C, serving as controls, received no specific anti-CMV prophylaxis. All patients were given the same sequential immunosuppressive therapy. Patient survival and graft function did not show any significant differences at 2 years follow up. The incidence of fever, CMV infections, dialysis and steroid bolus therapy were lower in group A, but without statistical significance. Patients receiving a graft from a CMV-AK-positive donor were at high risk of developing an infection or reactivation of CMV. A study examining this subgroup seems appropriate.

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