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Is tolerance a prospective for clinical research?
1Division of Cell and Molecular Biology, The Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
Summary
Achieving transplant tolerance remains a critical goal. This 1991 perspective questions if current scientific knowledge and imagination are sufficient to realize this clinical research aim.
Area of Science:
- Transplantation immunology
- Clinical research
Background:
- Transplant tolerance is a highly desired but elusive outcome in organ transplantation.
- The pursuit of tolerance is a central objective driving clinical research in the field.
Purpose of the Study:
- To assess the feasibility of achieving transplant tolerance based on the scientific knowledge and creative imagination available in 1991.
- To frame the pursuit of tolerance as a prospective goal for clinical research.
Main Methods:
- Conceptual analysis of the state of basic scientific knowledge in transplantation in 1991.
- Evaluation of the role of creative imagination in advancing transplantation research.
Main Results:
- The abstract poses a question rather than presenting empirical results.
- It highlights the aspirational nature of transplant tolerance.
Conclusions:
- The realization of transplant tolerance in 1991 was contingent upon the integration of scientific understanding and innovative thinking.
- The pursuit of tolerance necessitates a forward-looking approach in clinical research.