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Related Experiment Videos

White adipose tissue: getting nervous.

E Fliers1, F Kreier, P J Voshol

  • 1Academic Medical Center of the University of Amsterdam, Department of Endocrinology and Metabolism, Amsterdam, The Netherlands. e.fliers@amc.uva.nl

Journal of Neuroendocrinology
|November 19, 2003
PubMed
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White adipose tissue (WAT) is an active endocrine gland, not just a fat store. The central nervous system (CNS) regulates WAT function and body fat distribution, impacting metabolic health.

Area of Science:

  • Neuroendocrinology
  • Metabolic Physiology
  • Adipose Tissue Biology

Background:

  • White adipose tissue (WAT) is increasingly recognized as an endocrine organ.
  • WAT actively participates in regulating energy metabolism, appetite, and hormone sensitivity.
  • Neural regulation, including sympathetic and parasympathetic innervation, influences WAT function.

Purpose of the Study:

  • To investigate the role of the central nervous system (CNS) in regulating white adipose tissue (WAT).
  • To explore the functional parasympathetic innervation of WAT and its impact on body fat distribution.
  • To understand the link between CNS control of WAT and metabolic disorders.

Main Methods:

  • Review of neuroendocrine research on WAT.
  • Analysis of studies demonstrating functional parasympathetic innervation of WAT in rats.

Related Experiment Videos

  • Examination of the effects of parasympathectomy on glucose and fatty acid uptake and local hormone synthesis in WAT.

    • Main Results:

    • The CNS plays a significant role in regulating body fat distribution through neural control of WAT.
    • Parasympathetic innervation of WAT exhibits somatotopy, with distinct neuronal pathways innervating visceral and subcutaneous fat.
    • Parasympathectomy leads to insulin resistance in WAT and alters local hormone synthesis.

    Conclusions:

    • The CNS is crucial for regulating both hormone production and sensitivity in white adipose tissue (WAT).
    • Understanding CNS-WAT interactions offers insights into metabolic disorders like type 2 diabetes and lipodystrophy.
    • This research highlights WAT as a key neuroendocrine-adipose interface.