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Related Experiment Videos

Tissue chemoablation.

Jamil Rehman1, Jaime Landman, Chandrum Sundaram

  • 1Department of Surgery, Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri 92868, USA.

Journal of Endourology
|November 19, 2003
PubMed
Summary
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Tissue chemoablation using agents like ethanol, hypertonic saline, and acetic acid shows promise but faces challenges in predictability. Acetic acid demonstrated complete necrosis in a porcine kidney model, suggesting potential for future therapeutic applications.

Area of Science:

  • Regenerative Medicine
  • Oncology
  • Urology

Background:

  • Chemoablation utilizes chemical agents to induce tissue necrosis.
  • Current research explores chemoablation for various organs and cancers, including liver metastases and prostate cancer.
  • Existing human studies often involve non-surgical candidates or pre-surgical investigational procedures.

Purpose of the Study:

  • To review the current state of tissue chemoablation in animal and human studies.
  • To evaluate the feasibility, predictability, and reproducibility of necrosis induced by needle chemoablation in a porcine renal model.
  • To assess different chemoablative agents including ethanol, hypertonic saline, and acetic acid in solution and gel forms.

Main Methods:

  • A comprehensive literature search of MEDLINE for tissue chemoablation studies from 1965 to present.

Related Experiment Videos

  • Experimental chemoablation in a porcine renal model using 95% ethanol, 24% hypertonic saline, and 50% acetic acid solutions and gels.
  • Assessment of necrosis induced by the tested chemoablative agents.

    • Main Results:

    • Extensive literature exists on liver metastases chemoablation; prostate chemoablation is an emerging research area.
    • Animal studies on renal chemoablation as a sole therapy have yielded variable outcomes.
    • In the porcine model, only acetic acid effectively produced complete necrosis.

    Conclusions:

    • Ethanol chemoablation is currently feasible and reproducible primarily for metastatic hepatic carcinoma.
    • Chemoablation for prostate and kidney applications remains largely investigational in urology.
    • Irregular and unpredictable agent spread, even in gel form, is a significant limitation; future advancements may involve combining chemoablation with other energy sources like radiofrequency.