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Measuring adherence in a hypertension clinical trial
1Principal Investigator and Consultant in Nursing Research, Guest Researcher, University of Oslo, Oslo, Norway. glenys@mac.com
Insights
Medication adherence in hypertension varies significantly by measurement method. Electronic monitoring and self-report tools show differing adherence rates, impacting cardiovascular health outcomes.
Area of Science:
- Pharmacology
- Clinical Medicine
- Health Services Research
Background:
- Non-adherence to hypertension medication is a significant global health issue.
- Improving medication adherence is crucial for reducing cardiovascular mortality rates.
Purpose of the Study:
- To evaluate various methods for measuring medication adherence in hypertensive patients.
- To compare adherence data obtained from electronic monitoring, self-report, and other clinical measures.
Main Methods:
- A randomized clinical trial comparing study medication (potassium) versus placebo.
- Utilized the Medication Event Monitoring System (MEMS) for electronic adherence tracking.
- Incorporated capsule counts, self-report questionnaires, and physician estimates for comprehensive adherence assessment.
Main Results:
- Adherence measurements showed considerable variability, with electronic monitoring (MEMS) at 58% and self-report items related to forgetfulness at 46-55%.
- Other self-report measures and a general adherence scale indicated higher adherence rates (80-90%).
- Electronic monitoring demonstrated the strongest correlation with capsule counts at the fifth visit.
Conclusions:
- Different adherence measurement tools yield diverse results in hypertensive patients.
- Healthcare providers should consider the limitations and variations in adherence assessment methods.
- Further research is needed to optimize adherence monitoring strategies for better patient outcomes.
Background:
Non-adherence in hypertension is a global problem and promoting adherence is necessary to decrease cardiovascular mortality.
Aims:
The purpose of this paper is to examine the measurement of adherence to medication taking in hypertensive patients. Adherence was evaluated primarily by means of MEMS (Medication Event Monitoring System, Aprex Corporation, Fremont, California) an electronic system that records the date and time of opening of the study medication container. Additional measurements such as change in urinary potassium level, capsule count, client self report and physician estimate of adherence were recorded.
Methods:
A randomised clinical trial was used to assign patients to receive the study medication (potassium) or placebo. Descriptive statistics were used to answer the research questions. Frequency and percentage of responses to different measures of adherence were carried out as well as correlation between the measures.
Results:
One hundred and seven subjects between the ages of 26 and 80 participated in the clinical trial. The results showed that adherence measures varied with lowest adherence from two items of self-report related to forgetfulness (46 and 55%) and stringent electronic monitoring with the MEMS (58%) to percentages in the 80-90 range for other self-report items and the general adherence scale. Electronic monitoring correlated best with capsule count at visit 5. Implications for health care providers are discussed.
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