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[HELLP syndrome--4 case reports].

B Lorentzen1, M Endresen, T Henriksen

  • 1Kvinneklinikken, Aker sykehus, Oslo.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|October 20, 1992
PubMed
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HELLP syndrome, a severe pregnancy complication involving haemolysis, elevated liver enzymes, and low platelets, requires intensive care. Early diagnosis is crucial as it can develop rapidly and may not present with typical preeclampsia symptoms.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Hematology

Background:

  • HELLP syndrome (Hemolysis, Elevated Liver enzymes, Low Platelets) is a critical obstetric complication.
  • It is often considered a variant of severe preeclampsia, presenting with hemolysis, hepatic damage, and thrombocytopenia.
  • This condition can manifest pre-, intra-, or postpartum.

Observation:

  • Four case reports of HELLP syndrome are presented.
  • The syndrome can develop rapidly, sometimes within hours.
  • Many patients do not display overt signs of severe preeclampsia, often reporting non-specific symptoms like malaise, nausea, epigastric pain, and headache.

Findings:

  • Diagnosis is confirmed by the presence of hemolysis, elevated liver enzymes, and thrombocytopenia.

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  • The clinical presentation can be varied, making diagnosis challenging without laboratory confirmation.
  • Rapid onset and potential lack of typical preeclampsia symptoms are noted.

    • Implications:

    • HELLP syndrome necessitates immediate and intensive multidisciplinary care involving obstetricians, anesthesiologists, and hematologists.
    • Awareness of HELLP syndrome's varied presentation is vital for timely diagnosis and management.
    • Prompt recognition and management are critical for improving maternal and fetal outcomes in this serious pregnancy complication.