Related Experiment Video
Updated: Aug 19, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
Insulin receptor and ageing
Tamas Fulop1, Anis Larbi, Nadine Douziech
1Centre de Recherche sur le vieillissement, Institut Universitaire de Gériatrie, Service de Gériatrie, Département de Médecine, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Que., Canada J1H 4C4. tamas.fulop@usherbrooke.ca
Abstract:
The number of elderly people is increasing worldwide as well as the age-associated diseases, such as the type 2 diabetes. The consequences are disastrous for elderly patients as well as for healthy ageing. It has been clinically demonstrated that with physiological ageing it exists already a resistance to the action of insulin leading to slightly increased glycemia and insulin levels. Several causes have been postulated for this insulin resistance with ageing, among them the alteration of insulin receptor (IR) number, of IR signal transduction as well as environmental changes. Much more studies are needed to understand correctly the age-related changes of IRs mainly in humans. In this review, we will summarize our actual knowledge in the context of ageing on IRs trying to include it in a more general picture of receptor physiology with ageing. The understanding of the IR physiology with ageing will help to develop more adequate preventive and therapeutic strategies in order to decrease the burden of the complications related to insulin resistance.
Related Concept Videos
Insulin Secretory Vesicles
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are co-secreted in...
Insulin: The Receptor and Signaling Pathways
Insulin: Biosynthesis, Chemistry, and Preparation
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment primarily uses...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...

