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Updated: Aug 30, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
Catalase-peroxidase activity has no influence on virulence in a murine model of tuberculosis
Pere Joan Cardona1, Sergi Gordillo, Isabel Amat
1Unitat de Tuberculosi Experimental, Department of Microbiology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Crta del Canyet s/n, Badalona, 08916 Catalonia, Spain. pcardona@ns.hugtip.scs.es
Abstract:
The capacity to generate a chronic and persistent infection in the experimental murine model of tuberculosis induced aerogenically by a low-dose inoculum was determined in eight isoniazid-resistant clinical strains of Mycobacterium tuberculosis showing different catalase-peroxidase (C-P) activities. Determination of bacillary concentration in lung and spleen and the percentage of pulmonary parenchyma occupied by granulomas were monitored. Data showed no relation between the lack of C-P activity and the ability to develop a persistent infection, highlighting the potential of C-P negative strains to spread through the community.
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