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Collagen gel systems for sustained delivery and tissue engineering.

Donald G Wallace1, Joel Rosenblatt

  • 1dgwall317@yahoo.com

Advanced Drug Delivery Reviews
|November 19, 2003
PubMed
Summary

Collagen gels offer potential for injectable drug delivery, but controlling therapeutic molecule release remains challenging due to pore size and stability issues. Modifications are needed for effective sustained release and tissue engineering applications.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Tissue Engineering

Background:

  • Collagen gels are injectable and biocompatible, presenting potential as drug delivery matrices.
  • Sustained therapeutic molecule release from collagen matrices is difficult due to large pore sizes and rapid degradation.
  • Existing methods to control release, like binding or secondary matrices, increase system complexity.

Purpose of the Study:

  • To explore the potential and challenges of using collagen gels for drug delivery and tissue engineering.
  • To investigate methods for controlling therapeutic molecule release from collagen matrices.
  • To assess the suitability of collagen gels for cell retention and gene delivery.

Main Methods:

  • Analysis of collagen gel properties, including pore size and degradation rates.

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  • Evaluation of strategies for controlling drug release, such as covalent/non-covalent binding and secondary matrices.
  • Assessment of collagen gels' performance in tissue engineering contexts, including cell retention and gene delivery.

    • Main Results:

    • Fibrillar collagen gels have large pore sizes (tens of nanometers), hindering diffusion-based release control.
    • Non-fibrillar collagen gels offer smaller pore sizes (4-6 nm) but exhibit rapid in vivo dissolution (approx. 24 h).
    • Collagen gels are suitable for tissue engineering, acting as cell "cages" or gene delivery vehicles, though gel strength requires improvement.

    Conclusions:

    • Controlling drug release from collagen gels necessitates strategies beyond hindered diffusion, such as agent binding or secondary matrices.
    • Collagen gels show promise for tissue engineering applications, particularly for larger molecules like cells and gene complexes.
    • Enhancing collagen gel strength through reinforcement and alignment is crucial for improved performance in tissue engineering.