Related Experiment Video
Updated: Aug 4, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
Hydroxamic acids: proton donor and acceptor strength for use in drug design
1School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur, C.G. 492 010, India.
Abstract:
Hydroxamic acids, the naturally occurring and synthetic products, generally have low toxicities and are of interest for many therapeutic applications. The present investigation describes the measurement of hydrogen bond donor (HBD) strength of ten hydroxamic acids by measuring their log P(O/W) values. Hydroxamic acid functional group contains two oxygen and one nitrogen atom as the acceptor sites. Thus, HBA strength of these reagents is also computed. A knowledge of these parameters is valuable in the field of toxicology, pharmacology and environmental sciences.
More Related Videos
08:49Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis
Published on: June 20, 2025
10:29Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Related Concept Videos
Bronsted-Lowry Acids and Bases
Amino acids
Acid and Bases: Ka, pKa, and Relative Strengths
Acidity and Basicity of Carboxylic Acid Derivatives
The relative acidic strength of the derivatives can be explained based on the extent of resonance stabilization of the conjugate base. The...
Basicity of Aliphatic Amines
To measure the basicity of amines, two conventions are generally used. The first defines Kb as the basicity constant for the deprotonation reaction of water by the amine, as presented in Figure 1. Conventionally, lower Kb indicates higher...
Titration in Nonaqueous Solvents