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Related Experiment Videos

Possible involvement of plasma antioxidant defences in training-associated decrease of platelet responsiveness in

C Di Massimo1, P Scarpelli, M Penco

  • 1Laboratory of Applied Physiology, Department of STB, School of Medicine, University of L'Aquila, Via Vetoio, Coppito, 67100 L'Aquila, Italy.

European Journal of Applied Physiology
|November 19, 2003
PubMed
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Regular exercise training reduces platelet aggregation and enhances antioxidant defenses, including total antioxidant capacity (TEAC) and high-density lipoprotein cholesterol (HDL-C), in sedentary individuals.

Area of Science:

  • Exercise Physiology
  • Cardiovascular Health
  • Biochemistry

Background:

  • Sedentary lifestyles are associated with increased platelet reactivity and oxidative stress.
  • Platelet sensitivity plays a crucial role in cardiovascular disease pathogenesis.
  • The influence of exercise on platelet function and antioxidant status requires further elucidation.

Purpose of the Study:

  • To investigate the impact of a 20-week exercise program on ex vivo platelet responsiveness in sedentary individuals.
  • To explore the role of plasma antioxidant defenses in modulating platelet sensitivity post-exercise.
  • To examine the relationship between exercise-induced changes in antioxidant capacity, lipid profiles, and platelet function.

Main Methods:

  • A 20-week exercise training program was implemented in sedentary participants.

Related Experiment Videos

  • Ex vivo platelet aggregation was measured in response to adenosine diphosphate (ADP) and collagen.
  • Plasma levels of total antioxidant capacity (TEAC), superoxide dismutase activity, high-density lipoprotein cholesterol (HDL-C), and lipid peroxidation products were assessed.
  • Nitrate/nitrite (NOx) content in plasma and platelet cytosol was quantified.
  • In vitro low-density lipoprotein (LDL) oxidation lag time was determined.

    • Main Results:

    • Exercise training significantly decreased ADP- and collagen-evoked platelet aggregation.
    • Plasma TEAC, superoxide dismutase activity, and HDL-C concentration increased significantly post-training.
    • A significant increase in LDL oxidation lag time and a decrease in lipid peroxidation products were observed.
    • Plasma and intraplatelet NOx content significantly increased following the exercise intervention.
    • Correlations were found between lag time, TEAC, HDL-C, and NOx levels.

    Conclusions:

    • Moderate regular exercise improves antioxidant defenses, potentially desensitizing blood platelets.
    • Exercise-induced enhancements in antioxidant capacity, HDL-C, and NOx bioavailability may contribute to reduced platelet sensitivity.
    • These findings suggest a cardioprotective mechanism mediated by exercise through improved oxidative balance and reduced platelet hyper-reactivity.