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Updated: Aug 30, 2026

Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice
Published on: May 5, 2011
Bench-to-bedside review: microvascular and airspace linkage in ventilator-induced lung injury
John J Marini1, John R Hotchkiss, Alain F Broccard
1Professor, University of Minnesota, Regions Hospital, St Paul, Minnesota, USA. marin002@umn.edu
Abstract:
Experimental and clinical evidence point strongly toward the potential for microvascular stresses to influence the severity and expression of ventilator associated lung injury. Intense microvascular stresses not only influence edema but predispose to structural failure of the gas-blood barrier, possibly with adverse consequences for the lung and for extrapulmonary organs. Taking measures to lower vascular stress may offer a logical, but as yet unproven, extension of a lung-protective strategy for life support in ARDS.
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