Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Longevity studies in GenomEUtwin.

Axel Skytthe1, Nancy L Pedersen, Jaakko Kaprio

  • 1The Danish Twin Registry, Epidemiology Unit, Institute of Public Health, University of Southern Denmark, Odense, Denmark.

Twin Research : the Official Journal of the International Society for Twin Studies
|November 20, 2003
PubMed
Summary

Genetic factors influence lifespan, with extreme longevity clustering in families. This study uses large twin registries to analyze lifespan heritability and identify genetic variants for exceptional survival.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic and Environmental Effects on BMI Fluctuation Across the Adult Life Course and Its Associations With Baseline BMI and BMI Change: An Individual-Based Study of 14 Longitudinal Twin Cohorts.

Diabetes, obesity & metabolism·2026
Same author

Genetic and environmental effects on weight gain from young adulthood to old age and its association with body mass index in early young adulthood: an individual-based pooled analysis of 16 twin cohorts.

International journal of obesity (2005)·2025
Same author

Genetic and environmental effects on weight gain from young adulthood to old age and its association with body mass index at early young adulthood: an individual-based pooled analysis of 16 twin cohorts.

medRxiv : the preprint server for health sciences·2025
Same author

Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts.

International journal of obesity (2005)·2022
Same author

Concordance and comorbidities among monozygotic twins with tic disorders.

Journal of psychiatric research·2021
Same author

EWAS of Monozygotic Twins Implicate a Role of mTOR Pathway in Pathogenesis of Tic Spectrum Disorder.

Genes·2021

Area of Science:

  • Genetics
  • Epidemiology
  • Gerontology

Background:

  • Twin studies suggest 25% of lifespan variation is genetic.
  • Moderate familial clustering of extreme longevity has been observed.
  • GenomEUtwin provides a unique resource for longevity research.

Purpose of the Study:

  • To discuss definitions and analytical approaches for extreme longevity, including censored data challenges.
  • To outline possibilities for longevity studies within the GenomEUtwin consortium.
  • To extend lifespan analyses in Danish twin cohorts and enable heritability studies.

Main Methods:

  • Utilizing Lexis diagrams for Danish, Dutch, Finnish, Italian, Norwegian, and Swedish Twin registries.
  • Extending lifespan analyses to include Danish twin cohorts from 1901-1910.

Related Experiment Videos

  • Leveraging population-based, nationwide health and death registers for epidemiological studies.

    • Main Results:

    • Findings are consistent with previous analyses of Danish twin cohorts.
    • The GenomEUtwin sample size and linked registers enable powerful epidemiological studies.
    • The study provides a resource for identifying sibships with extreme longevity.

    Conclusions:

    • GenomEUtwin facilitates powerful epidemiological studies of longevity and lifespan heritability.
    • The resource can aid in discovering genetic variants associated with extreme survival.
    • Further research can explore age-specific heritability and genetic factors in longevity.