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[Sex differentiation disorders from the andrologic viewpoint]
W Weidner1, G Zöller, R H Ringert
1Klinik und Poliklinik für Urologie der Georg-August-Universität Göttingen.
Der Urologe. Ausg. A
|November 1, 1992
Summary
Managing ambiguous genitalia in neonates requires early diagnosis and intervention. Later management focuses on andrological issues like identity, sexuality, and fertility, considering genetic, gonadal, and phenotypic factors.
Area of Science:
- Endocrinology
- Pediatric Surgery
- Genetics
Context:
- Abnormal sex differentiation presents with ambiguous genitalia in neonates.
- Early diagnosis and phenotypic gender assignment are crucial.
- Management becomes complex during puberty and adulthood.
Purpose:
- To outline the diagnostic and management challenges of abnormal sex differentiation.
- To address andrological concerns from puberty onwards.
- To emphasize a comprehensive approach considering pathogenesis and disease course.
Summary:
- Abnormal sex differentiation necessitates prompt neonatal evaluation, gender assignment, and surgical correction.
- Later management involves andrological guidance for identity, sexuality, and fertility.
- Potential issues include hypogonadism, micropenis, undescended testes, lack of secondary sex characteristics, impotence, and infertility.
Impact:
- Informs clinical practice for managing ambiguous genitalia across different life stages.
- Highlights the importance of individualized treatment plans.
- Improves long-term outcomes for patients with disorders of sex development.